Drusilla from Buffy the Vampire Slayer
From childhood, Drusilla was already possessed with physical powers. Angelus tortured her to insanity and eventually turned her into a vampire. Angelus killed her entire family before her eyes because he wanted to turn her into his very own machine. Drusilla eventually turned on the young poet William Pratt who later became her paramour.
However, she was weakened when a mob in Prague captured her. William Pratt, searching for a cure for her, took her to Hellmouth in Sunnydale. The city was guarded by Buffy Summers. Is she one of your favorite vampires too?